Carcinogenesis, Teratogenesis & Mutagenesis ›› 2000, Vol. 12 ›› Issue (4): 193-195.doi: 10.3969/j.issn.1004-616x.2000.04.001

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THE REGIONAL DISTRIBUTION OF CYP1A1 mRNA IN RAT BRAIN AND THE EFFECT OF DELTAMETHRIN ON THE EXPRESSION OF CYP1A1

LIU Lie-gang , YAN Hong , SHI Nian , L IU Yu-gu   

  1. Department of Envi ronmental of Toxicology , Tongji Medical University , Wuhan 430030 , China
  • Received:1998-11-24 Revised:1999-11-30 Online:2000-10-30 Published:2000-10-30

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Abstract: Purpose : The purpose of the present study was to investigate the regional dist ribution of CYP1A1 mRNA in rat brain and the effect of Deltamethrin on CYP1A1 gene expression. Methods : By the methods of RT2PCR and dot blot analysis. Results : By the methods of RT2PCR and dot blot , it was revealed that the regional dist ribution of CYP1A1 mRNA varied in different brain ; Deltamethrin inhibited the expression of CYP1A1 mRNA , especially in cerebral cortex , under the t reatment of Deltamethrin with the dose of 12. 5mg.kg - 1 . d - 1 ip. for five days. Conclusion : These result s demonst rated that Deltamethrin markedly inhibited CYP1A1 gene expression.

Key words: Deltamethrin, CYP1A1 mRNA, RT - PCR

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